Super-resolution microscope visualizing cellular structures and molecular activity at resolutions never before achieved by conventional light microscopy.
Nikon’s new N-SIM microscopy system can produce nearly two times the resolution of conventional optical microscopes by combining Structured Illumination Microscopy technology licensed from UCSF and based on the world renowned Eclipse Ti research inverted microscope with Nikon’s legendary CFI Apo TIRF 100x oil objective lens (N.A. 1.49), developed using unique optical technologies and manufacturing techniques. N-SIM also delivers the fastest imaging capability in the industry, with a time resolution of 0.6 sec/frame.
Nearly Double the Resolution of Conventional Optical Microscopes
N-SIM nearly doubles the resolution of conventional optical microscopes by combining “Structured Illumination Microscopy” technology licensed from UCSF with Nikon’s renowned CFI Apo TIRF 100x oil objective lens (N.A. 1.49).
Time Resolution of 0.6 sec/frame, the Fastest in the Industry
N-SIM provides the fastest imaging capability in the industry, with a time resolution of 0.6 sec/frame, effective for live-cell imaging.
TIRF-SIM Imaging Technique
The newly developed TIRF-SIM illumination technique enables Total Internal Reflection Fluorescence (TIRF) observation with higher resolution than conventional TIRF microscopes and gives more detailed structural information near the cell membrane.
The new 3D-SIM illumination technique has the capability of optical sectioning of specimens, enabling the visualization of more detailed cell structures at higher spacial resolutions up to 20μm in thickness.